Fisetin: The Flavonoid with Anticancer & Anti-aging Potential

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Have you heard of the flavonoid fisetin? Recent research has shown that fisetin can increase the lifespan of mice by about 10%. Clinical trials are currently being done to determine the effectiveness of fisetin in humans.

Fisetin is a natural flavonoid present in fruits and vegetables such as strawberries, apples, onions, and cucumbers. It possesses multiple pharmacological activities such as anticancer, anti-inflammatory, and antioxidant effects.

Anticancer Potential

According to research published by the Journal of Cell Death & Disease, fisetin has antitumor effects in various cancer models. It is effective against pancreatic cancer, one of the most aggressive types of cancer associated with poor survival rates.

  • The 5-year survival rate of pancreatic cancer is 6% because of chemotherapy resistance and early metastasis.
  • Most pancreatic cancer patients are usually symptomless; therefore, less than 20% of these patients receive an early diagnosis.
  • A study published in the International Journal of Cancer shows that fisetin inhibits the growth of pancreatic cancer cells through DR-3 mediated inhibition.
  • Research shows that in colon cancer cells, fisetin induces apoptosis.
  • Fisetin causes mitochondria-dependent apoptosis in gastric cancer cells.
  • The antitumor mechanism of fisetin is cancer-cell specific.

Anti-Aging Potential

Anti-aging scientists believe that fisetin slows down aging by making cells more efficient and decreasing inflammation. As you get older, cells stop dividing triggering inflammation and age-related diseases. Fisetin will promote rapid cell division and reverse aging.

Fisetin & Stress

Fisetin protects your cells from stress-related damage. This enables your cells to run at full power. It helps your body to create more glutathione; a very powerful anti-inflammatory chemical.

The-Bottom Line

Fisetin is one of the flavonoids with many unique health benefits. Foods that are rich in fisetin include grapes, persimmons, onions, cucumbers, and strawberries. You should eat these foods regularly.

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